Breaks down the main component of connective tissue interstitial substance – hyaluronic acid (mucopolysaccharide, which consists of acetylglucosamine and glucuronic acid, is the cementing substance of connective tissue) and reduces testosterone suspension cycle its viscosity, increases the tissue and vascular permeability, facilitates the movement of fluids in the interstices spaces; reduces tissue swelling, softens and flattens scars, increases the amount of motion in the joints, reduces contracture and prevents their formation. Hyaluronidase causes the breakdown of hyaluronic acid to glucosamine and glucuronic acid and thereby reduces its viscosity. The duration of action when administered intradermally – up to 48 hours.
Burn, traumatic, post-surgical scars; nonhealing ulcers (including radiation); Dupuytren’s contracture; joint stiffness, joint contractures (after inflammation, injuries), osteoporosis, ankylosing spondylitis, severe disease of lumbar disc; chronic tenosynovitis, scleroderma (skin manifestations), the soft tissue hematoma surface localization; preparations for dermatological and plastic surgery on the scar nodules. Tuberculosis of the lungs (bronchi complicated by nonspecific lesions), inflammation of the upper respiratory tract and bronchi with obstruction phenomena. Traumatic lesions of nerve plexus and peripheral nerves (plex neuritis).Hyphema, hemo-ftalm, retinopathy of various etiologies.
Hypersensitivity, acute infectious and inflammatory diseases, recent hemorrhage, acute intercurrent disease, children under 18 years. For inhalation – pulmonary tuberculosis with severe respiratory failure; lung, bleeding, coughing up blood; malignancies, fresh vitreous hemorrhage. Concomitant estrogen. Data on the use of the drug have no children.
Dosage and administration:
When scarring lesions of subcutaneous (under the scar-altered tissue) or intramuscularly (near the site of injury) administered 64 CU (1 ml) daily or every other day (a total of 10-20 injections).
In traumatic lesions of nerve plexus and peripheral nerves is administered subcutaneously to the affected nerve (64 UE in procaine solution) every other day; a course – 12-15 injections. The course of treatment is repeated as needed.
When used in ophthalmic practice, the drug is administered subkonyunktivalno – 0.3 ml, parabulbarno – 0.5 mL, and electrophoresis.
Patients with pulmonary tuberculosis with the productive nature of inflammation is administered in combination therapy for increasing the concentration of antibacterial drugs testosterone suspension cycle in lesions by injection and / or inhalation; Inhalation is administered daily one time with 5 ml (320 CU). The course of treatment consists of 20-25 inhalation. If necessary to repeat courses at intervals of 1.5-2 months.
Outwardly, in the form of dressings impregnated with the drug solution. To prepare the solution every 64 UE dissolved in 10 ml of sterile 0.9% sodium chloride solution or boiled water at room temperature.This solution is wetted with a sterile bandage, folded in 4-5 layers, applied it to the affected area, cover with waxed paper and fix soft bandage. The dose depends on the area affected (20-60 iu / sq cm.), On average – 300 ME on the bandage. The bandage is applied daily for 15-18 hours for 15-60 days. With prolonged use every 2 weeks make a break for 3-4 days.
When using electrophoresis method ME 300 was dissolved in 60 ml of distilled water, add 2-3 cap of 0.1% hydrochloric acid solution and injected from the anode to the affected area for 20 -30 min. The treatment course – 15-20 sessions. The applicator dosing regimen can be alternated with electrophoresis. The prepared solution should be used within 24 hours.
Allergic reactions; long-term use – local irritating effect.
Overdose Symptoms: fever, nausea, vomiting, dizziness, tachycardia, decreased blood pressure, local swelling, urticaria, erythema. Treatment: administration of epinephrine, corticosteroids; antihistamines.
Interaction with other drugs
improves the absorption of drugs administered subcutaneously or intramuscularly, enhances the effect of local anesthetics.
solution should not be injected through the catheter in which solutions containing cations previously injected. Injectable testosterone suspension cycle solutions are prepared by 0.9% sodium chloride or 0.5% solution of procaine solution for inhalation – 0.9% sodium chloride solution for electrophoresis -. In distilled water
to test intradermal injection with 20 Before treatment advisable l of hyaluronidase.
It should not be administered in the area of infectious inflammation and swelling. In acute hemorrhages hyaluronidase does not apply.