The drug blocks the peripheral units of the cough reflex due to the following effects:
- a local anesthetic effect, which reduces the excitability of peripheral sensory (cough) testosterone suspension gains respiratory tract receptors;
- bronchodilator actions, through which there is suppression of the stretch receptors involved in the cough reflex;
- a slight decrease in activity of the respiratory center (without respiratory depression)
Antitussive effect of the drug is approximately equal to that of codeine. Prenoxdiazine does not cause addiction and drug dependence. In chronic bronchitis marked anti-inflammatory effect prenoxdiazine.
Prenoxdiazine does not affect the central nervous system function, except for the possible indirect anxiolytic action.
Prenoxdiazine rapidly and largely absorbed from the gastrointestinal tract. Maximum plasma concentration achieved prenoxdiazine 30 minutes after taking the drug, its therapeutic concentration is maintained for 6-8 hours. Relationship to plasma proteins is 55-59%. The half-life is 2.6 hours. Most of the dose is metabolized in the liver, only about 1/3 of the dose of the drug is excreted unchanged in, and the rest – in the form of metabolites (emphasis prenoxdiazine metabolite 4). During the first 12 hours prenoxdiazine metabolism the most important role played by biliary excretion and its metabolites. After 24 hours, after ingestion is allocated 93% of the formulation. For 72 hours after ingestion of 50-74% of the dose is excreted in the faeces and 26-50% – with urine.
Nonproductive cough of any origin (for catarrh of the upper respiratory tract, flu, acute and chronic bronchitis, testosterone suspension gains pneumonia, emphysema, night cough in patients with heart failure, preparing patients for bronchoscopic or bronhograficheskomu study).
Hypersensitivity to the drug.
Diseases associated with abundant bronchial secretion.
Condition after inhalation anesthesia.
Galactose intolerance, lactase deficiency or glucose-galactose malabsorption. Precautions: children’s age.
Pregnancy and lactation
During pregnancy and lactation use libeksin possible only if the potential benefit to the mother outweighs the potential risk to the fetus or child.
Dosing and Administration
The average dose for adults is 100 mg three or four times a day (1 tablet 3-4 times a day). In more complex cases, the dose can be increased up to 200 mg three – four times or 300 mg three times a day (2 tablets 3-4 times daily or 3 tablets 3 times a day).
The average dose for children, according to the age and body weight, or 25-50 mg three to four times a day (1/4 – 1/2 4/3 tablet twice a day). The maximum single dose for children – 50 mg (1/2 tablet), for adults – 300 mg (3 tablets). The maximum daily dose for children – 200 mg (2 tablets), for adults – 900 mg (9 tablets). In preparation for bronchoscopy dose of 0.9 – 3.8 mg / kg body weight is combined with 0.5 – 1 mg atropine for 1 hour prior to the procedure.
The tablets swallowed without chewing (to avoid mucosal anesthesia mouth).
Rare: skin rash, angioedema. On the part of the gastrointestinal tract Rare: dry mouth or throat, anesthesia (temporary numbness and loss of sensitivity) of the oral mucosa. Less than 10% of cases: stomach pain, addiction constipation, nausea. From the nervous system (when using the drug in high doses): light sedation, fatigue. it should be emphasized that, as the sedation and fatigue, occur at doses above the therapeutic, and all the symptoms spontaneously stopped within testosterone suspension gains a few hours after discontinuation of the drug